Exam Name: Clinical Trials Programming Using SAS 9.4
Certification Provider: SASInstitute
Corresponding Certification: SAS Clinical Trials Programming
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Updated: Sep 16, 2026
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SASInstitute A00-282 Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Validate Clinical Trial Data Reporting | 20% | - Validation principles - Use PROC COMPARE and log review - Programming validation techniques |
| Topic 2: Report Clinical Trials Results | 10% | - PROC REPORT and PROC PRINT - Produce tables, listings, and figures |
| Topic 3: Apply Statistical Procedures for Clinical Trials | 15% | - Basic statistical analysis for clinical data - PROC MEANS, FREQ, TABULATE |
| Topic 4: Regulatory Submissions | 5% | - ICH and FDA guidelines - Compliance for clinical data reporting |
| Topic 5: Clinical Trials Process | 5% | - Clinical trial lifecycle and protocol - Derive programming requirements from protocol and CRF |
| Topic 6: Manage Clinical Trials Data | 5% | - Use SQL and dictionary tables - Clean, merge, and subset data - Access and explore clinical datasets |
| Topic 7: Clinical Trials Data Structures | 10% | - Clinical domain structures - CDISC standards: SDTM, ADaM - Define.xml and dataset specifications |
| Topic 8: Macro Programming for Clinical Trials | 15% | - Macro variables and parameters - Debugging macros - Create and call macros |
| Topic 9: Transform or Summarize Clinical Trials Data | 15% | - Derive variables and study days - Aggregation and transposition - Data step manipulation |
SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:
Which statement correctly adds a label to the data set?
- A. DATA two Label="Subjects having duplicate observations"; set one; run;
- B. DATA two; Label="Subjects having duplicate observations"; set one; run;
- C. DATA two (Label="Subjects having duplicate observations"); set one;
- D. DATA two; set one; Label dataset="Subjects having duplicate observations"; run;
Correct Answer: C 🗳️
The print below shows the first four observations from the TEST2 dataset.
Variable names are given in the first row.
The statistical analysis plan (SAP) requests that a two sample t-test be performed to compare the mean of variable FINALBP for levels of the variable TRT.
You review the following code from a colleague:
proc ttest data=test2;
by trt;
var finalbp;
run;
This code does not produce the analysis requested by the SAP.
What is wrong with this code?
- A. Variable FINALBP should be specified on a TEST statement instead of a VAR statement.
- B. Variable FINALBP should be specified on a TWOSAMP statement instead of a VAR statement.
- C. Variable TRT should be specified on a CLASS statement instead of a BY statement.
- D. Variable TRT should be specified on a WEIGHT statement instead of a BY statement.
Correct Answer: C 🗳️
The following SAS program is submitted:
proc univariate date=work.STUDY; by VISIT; class REGION TREAT; var HBA1C GLUCOS; run; You want to store all calculated means and standard deviations in one SAS data set.
Which statement must be added to the program?
- A. ods output mean=m1 m2 std=s1 s2;
- B. output mean std;
- C. ods output out=WORK.RESULTS mean=m1 m2 std=s1 s2;
- D. output out=WORK.RESULTS mean=m1 m2 std=s1 s2;
Correct Answer: D 🗳️
This question will ask you to provide lines of missing code.
Which ODS statements, inserted respectively in the two locations indicated above, create a report stored in a PDF file?
- A. ods pdf file='AE.pdf';
ods pdf close; - B. ods file open='AE.pdf' type=pdf;
ods file close; - C. ods pdf open='AE.pdf';
ods pdf close; - D. ods file pdf='AE.pdf';
ods file close;
Correct Answer: A 🗳️
The programmer runs a validation program of the SDTM DM domain which produces the following in the log in SAS:
What does the validator need to check?
- A. The labels of both the production and validation datasets.
- B. The internal data values for SEX and AGE.
- C. The formatted data values for SEX and AGE.
- D. The sort order of both the production and validation datasets.
Correct Answer: B 🗳️
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